http://dspace.univ-relizane.dz/home/handle/123456789/192 2026-07-02T12:48:44Z http://dspace.univ-relizane.dz/home/handle/123456789/988 Title: Existence and Uniqueness of Solutions for Impulsive Fractional Partial Differential Equation Boundary Value Problems with theψ−Caputo Derivative under the Weak Topology. Authors: Zineb BELLABES Abstract: In this thesis, we study existence, uniqueness, and stability results for several classes of fractional differential equations in Banach spaces. We consider initial value problems for sequentialψ-Caputo fractional Langevin equations, boundary value problems involving impulses with power law kernels, a variable order Caputo thermistor model, and variable order Riemann-Liouville boundary value problems with multi-point data. The analysis is carried out in the weak topology framework using the Pettis integral, the De Blasi mea- sure of weak noncompactness, and fixed-point theorems of M¨onch, Schauder, Banach con- traction, and Krasnoselskii. Existence is proved via M¨onch’s theorem, uniqueness via the Banach contraction principle, and generalized Ulam-Hyers-Rassias stability is established. For the variable order thermistor problem, existence and uniqueness are obtained by split- ting the order into piecewise constant subintervals and applying Schauder’s and Banach’s theorems. For the Riemann-Liouville problem, the method of upper and lower solutions combined with Schauder’s theorem yields positive solutions in a fractional Sobolev space. Numerical examples illustrate the theoretical findings 2025-01-01T00:00:00Z http://dspace.univ-relizane.dz/home/handle/123456789/985 Title: EFFET DES DECHETS DE BETON BITUMINEUX SUR LE COMPORTEMENT DU BETON COMPACTE AU ROULEAU Authors: Ali Kouadri Fadhila Abstract: Le béton compacté au rouleau (BCR) présente des performances prometteuses pour les infrastructures routières, mais son utilisation reste limitée en Algérie. Cette étude propose une approche innovante consistant à développer un béton compacté au rouleau à partir de matériaux locaux, en substituant une partie des granulats traditionnels par des déchets de béton bitumineux recyclés. Le double objectif est de promouvoir l'utilisation du BCR comme matériau de revêtement durable, tout en valorisant les déchets de construction afin de réduire les coûts et l'impact environnemental. Nous avons analysé les propriétés physiques, mécaniques et hydrauliques de ces mélanges de béton sous des températures élevées, en mettant un accent particulier sur leur durabilité dans des conditions sévères (telles que l'expositionàl'acide sulfurique, la perméabilité). Ces essais sont déterminants, car ce béton peut être utilisé à proximité des réseaux d'assainissement, où les transferts d'eau et la corrosion chimique constituent des défis majeurs. Une modélisation tridimensionnelle d'un revêtement en béton de ciment rigideàl'aide du logiciel ANSYS 16.0, en introduisant la loi de comportement du béton correspondante dans le code. Cette modélisation aétéréalisée pour plusieurs cas de chargement sur des dalles en béton de ciment. 2025-01-01T00:00:00Z http://dspace.univ-relizane.dz/home/handle/123456789/984 Title: Phytochemical analyses and biological activities of selected medicinal plant extracts: bioactive nutrition and pharmaceutical resources Authors: MEDJADJI Bochra Abstract: This study was initiated to conduct an ethnobotanical survey among herbalists in the Wilaya of Relizane, Algeria, highlighting the cultural and therapeutic significance of two major medicinal plants: Ptychotis verticillata Duby and Thymus vulgaris L. These species, widely used in local phytotherapy, were subjected to a detailed analysis of their essential oils extracted by hydrodistillation to evaluate their in vitro biological activities, supported by molecular docking studies and pharmacokinetic and toxicological (ADMET) predictions. The hydrodistillation process yielded 1.2% (w/w) and 1.5% (w/w) essential oils from Ptychotis verticillata Duby and Thymus vulgaris L., respectively. Gas chromatography-mass spectrometry (GC-MS) analyses confirmed the chemical complexity and richness of these mixtures, identifying thymol as the predominant compound at 38.4% in T. vulgaris and carvacrol at 29.7% in P. verticillata, along with other monoterpenes. Biological assays demonstrated significant antioxidant activity via DPPH radical scavenging, with IC50 values of 45.3 ± 2.1 µg/mL for P. verticillata and 38.7 ± 1.8 µg/mL for T. vulgaris, compared to ascorbic acid (IC50 = 12.4 ± 0.9 µg/mL). Notable anti-inflammatory effects were evidenced by erythrocyte membrane stabilization and inhibition of protein denaturation, with inhibition rates of 65.2 ± 4.3% and 69.8 ± 3.7%, and 61.5 ± 2.9% and 67.3 ± 3.1%, respectively, at 100 µg/mL. The essential oils also exhibited effective insecticidal activity against Aphis spiraecola, inducing 78% mortality at 0.5% after 24 hours. Regarding antimicrobial efficacy, these oils exhibited marked inhibition against pathogenic strains, including Escherichia coli, methicillin-sensitive and resistant Staphylococcus aureus, and Enterococcus faecalis, producing inhibition zones of 18.5 ± 0.7 mm, 20.3 ± 0.9 mm, 15.9 ± 1.0 mm, and 19.1 ± 0.8 mm, respectively. Synergistic interaction between the essential oils of Ptychotis verticillata Duby and Thymus vulgaris L. enhanced their potential as natural antimicrobial agents, in some cases outperforming certain conventional antibiotics. Molecular docking analyses of three bacterial target enzymes revealed promising binding affinities of -7.6 to -9.1 kcal/mol for the major identified compounds, suggesting relevant competitive inhibition mechanisms. In silico studies of pharmacokinetic and toxicological properties predicted high intestinal absorption (>85%), moderate blood-brain barrier permeability, low acute toxicity (LD50 > 2000 mg/kg), and a moderate risk of skin sensitization for some molecules. Nutritional analysis of the plants revealed a balanced composition, characterized by high total carbohydrate content, moderate protein levels, low lipid content, and a slightly acidic pH, supporting their traditional use in phytotherapy and as potential nutritional supplements. Based on these data, a topical pharmaceutical formulation named "Derma Phyto Calm" was developed, incorporating essential oils of Ptychotis verticillata Duby and Thymus vulgaris L. enriched with natural vitamin E to enhance antioxidant stability. This natural product aims to exploit the oils' antimicrobial and anti-inflammatory properties, offering a promising phytotherapeutic alternative for treating inflammatory and infectious skin conditions, including intimate areas. Furthermore, given their low toxicity, these plants could also be used in infusion form as an accessible nutritional supplement for sensitive populations. This research exemplifies a rigorous integration of traditional knowledge with contemporary scientific methodology, encouraging the sustainable exploitation of Algerian medicinal plant resources and emphasizing ongoing biomedical research to valorize their therapeutic potential fully. 2025-01-01T00:00:00Z http://dspace.univ-relizane.dz/home/handle/123456789/983 Title: تأثير توجيهات السياسة الجنائية الحديثة على التشريعات الوطنية في معاملة الطفل الجانح – دارسة مقارنة- Authors: سفير أنفال Abstract: تكشف الدارسة عن كيفيات تكريس و تجسيد المشرع الجزائري للقواعد و المبادئ الدولية ذات الصلة بمجال حماية الطفولة الجانحة وفي تشريعه الوطني قياسا ببعض التشريعات المقارنة الأخرى .في ظل مسعى السياسة الجنائية الحديثة تم إفراد الطفل بنصوص قانونية خاصة في قانون رقم15/12 الذي يعد مكسبا هاما في تحديد السياسة الحديثة التي تميز معاملة الطفل الجانح أثناء إجراءات المتابعة و التحقيق القضائي مرورا بمرحلة المحاكمة و التي يتم خلالهم التركيز على الحماية القانونية بإقرار جملة من الضمانات القانونية و الحقوق مراعاة لمصلحته الفضلي و مع تطور العدالة الجنائية اتجه المشرع الجزائري صوب الية الوساطة الجزائية في مجال قضاء احداث كنموذج جديد لها و العمل على تبني أسس هادفة إلى إصلاحه و إعادة التأهيل أدماجه في المجتمع بعيدا عن سياسة القمع و العقاب باتخاذ الملائمة لوضعية الطفل الجانح 2025-01-01T00:00:00Z